Dicalcium Phosphate (DCP) USE: Mixed with other ingredients in animal feeds, DCP is mainly designed for breeding purposes (cattle, poultry...).Used as the main source of Phosphorus and Calcium, DCP strenghens the skeleton and accelerates the animal’s growth. Flowability is a crucial element of the manufacturing process. Drug Topics (online). The "di" prefix in the common name arises because the formation of the HPO42– anion involves the removal of two protons from phosphoric acid, H3PO4. JavaScript seems to be disabled in your browser. Inorganic chemical compound with the formula CaHPO 4. Fill out your details and our team will provide you with a full quote as soon as possible. Enter your details to get the User manual, Spec Sheet and Video links for the Dicalcium Phosphate. Usual Adult Dose for Hypocalcemia: 1 to 2 tablets orally once a day. How to use Calcium Phosphate, Dibasic 825 Mg Calcium/2.8 Gram Oral Powder. Calstar® Dicalcium Phosphate, Dihydrate Granular is a white granular USP grade of Dicalcium Phosphate Dihydrate used as a calcium and/or phosphorus nutrient supplement in pharmaceuticals and multivitamins. The prices are set on these quantities as it is the amounts that will fit on pallets. If your product is still sticky at this point then we would recommend looking into granulation. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. How long is the storage period of each excipient? Learn whether this means taking calcium phosphate supplements can give you healthier bones. Values. It can also be used as a filler for capsules. If you are storing them on the machine then make sure the machine is in a temperature controlled environment with low humidity. Good at binding tablets and making them bigger. Incorrect storage can affect the hardness of the tablet over time.Â. It is important to ensure that all parts are thoroughly dried immediately after washing to avoid any rusting. Which excipient should I add if the product is sticky? If your product does not bind well then we would recommend using MCC. Di-calcium Phosphate is an effective flowing agent that will contribute nutrients to your formula. It can be added to many foods as a supplement to contribute to both a humans and animals well-being. Lubricate - You now need to lubricate any parts that require it. Select one or more newsletters to continue. It is available in different hydrate forms and in a special particle size range. You can do this using a hover/vacuum. It is also known as E341. Titanium dioxide – a colourant used to make tablets and capsules bright white. As a nutritional supplement, Dicalcium Phosphate can be used in a wide variety of industries including: food production, pharmaceutical, cosmetics, agriculture/animal feed, and various other industries. How should I clean contact parts that have come into contact with my excipients or active ingredients? Dicalcium phosphate is the calcium phosphate with the formula CaHPO4 and its dihydrate. Manufacturers add it to cosmetics; doctors use it for healing; and you can take it to get more phosphorus and calcium. We advise that you use our Firmapress ready mix as this works with 99% of products. 2H 2 O) is the most stable phase themodynamically when pH is 4.2 or lower (Fig. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed March 24, 2012. We do not recommend that you add more than 1% to the mix as more than this can cause capping. Averages as fed / on DM / other unit Min/max as fed Min/max on DM Min/Max other unit Main constituents; Parameter Do any of the excipients increase the speed of damage to tooling? In Beverage. Dicalcium Phosphate E341(ii) can be used in beverage. ).Some health conditions may make you more susceptible to the side-effects of the drug. Make sure that the vacuum you are using has a filter good enough to handle fine dust. If your product is sticky then you will need to add a dry lubricant to your mix. LFA's Di-Calcium Phosphate is directly compressible. It is one of the main calcium phosphates used in animal feeding. This can be done with warm water and soap or if available an ultrasonic cleaner. You do not have to do this if you used an ultrasonic cleaner in the last step. Diluents are added to pharmaceutical tablets or capsules to make the product large enough for swallowing and handling, and more stable.[1]. For more information please visit the individual product pages. This stops products from getting stuck to the tooling. Yes, all of the excipients are safe for human or animal consumption. However, too much dicalcium phosphate, or dicalcium phosphate taken in conjunction … In cosmetics and personal care products, the Calcium Phosphate ingredients are used in the formulation of blushers, dentifrices, eye makeup, eyeliners, face powders, foundations, lipsticks, other makeup products and skin care products. Tablet Flowing Issues Troubleshooting Guide, Skip to the beginning of the images gallery. here are 6 steps that should be followed as a general rule of thumb when cleaning contact surfaces that have come into contact with powders: Dry Clean - First you need to remove as much of the dry powder as possible. This is a product that consumers are familiar with and makes the perfect addition to your tablet. Which excipient should I add if the product/API is clumpy? For this, we recommend silicon dioxide. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Please note that Magnesium Sterate does not bind by itself. 2H 2 O. Therefore, mixture of calcium phosphate powder which supply Ca 2+ and PO 4 3 − ions and the pH of the paste is 4.2 or lower could be the brushite cement. It has a large mesh so it flows well but most people do not like it because of the intolerance issues. Microcrystalline Cellulose is a binding agent, which holds the content of the tablet together. It has the chemical formula Ca3(PO4)2. It ensures that your ingredients will run through machinery with ease. It is unlikely that you will be able to produce tablets without using any Excipients at all. Di-Calcium Phosphate is highly soluble in citric acid and ammonium citrate. It is used in pharmaceutical or over-the-counter (e.g., multivitamin) products.… Rinse - Next you need to rinse off any soap with potable water (drinking water). What kind of condition should excipients be stored in? Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Certain products do bind without Excipients, but then do not flow through the machine. When two water molecules are bound to Dicalcium Phosphate it is called Dicalcium Phosphate Dihydrate. Are all excipients safe for all ages to consume? Averages as fed / on DM / other unit Min/max as fed Min/max on DM Min/Max other unit Main constituents; Excipients in your Mix - Making a Tablet Mix, Making a Tablet Pill Mix - Making a Test Mix, Calculating Bulk Density - Making a Tablet Pill Mix, https://www.lfatabletpresses.com/product-data. Magnesium Stearate is a dry lubricant and helps again with the movement of ingredients through the machine but also helps with the ejection of the tablets from the machine. There are some precautions that should be taken when handling them and there are some people that might have intolerances to some of them. We only recommend adding a maximum of 2% of this to the mix. It is generally recognized as safe by the US Food and Drug Administration. Firmapress is an all in one mix of Microcrystalline Cellulose, Magnesium Stearate and Dicalcium Phosphate. Other examples of bulking agents used in tablet manufacture include mannitol, dicalcium phosphate, calcium sulfate, dry starch, cellulose, kaolin, sodium chloride, anhydrous lactose, sorbitol, sucrose etc. Dextrose - approx 100 meshDicalcium Phosphate - approx 100 meshMicrocrystoline Cellulose - approx 120-200Magnesium sterate - Lactose - 80 meshSilica Dioxide - Firmapress - 100-200 mesh. Dextrose - Sweetener, binding agent, good for chewable tablets or candy. Dicalcium Phosphate is a flowing agent and helps move ingredients through the machine before they are compressed. Due to it's alkalinity it wont work with some acidic active ingredients. Di-Calcium Phosphate binding properties are only moderate. This can be used in any % the limiting factor is the size of the tablet. A review of the marketed tablets and capsules indicated that several of them contain calcium phosphate. We offer Microcrystalline Cellulose, Magnesium Stearate, Dicalcium Phosphate and Firmapress in our range of excipients. Using excipients like Di-calcium phosphate reduces the effort taken to create new formulas. Another prominent use for Di-calcium Phosphate is in animal feed. It is often included in breakfast cereals, flour and noodle products. When handling, you should use protective eye gear, gloves and an inhalation mask. Yes, it does not matter what age, size or sex the person is consuming the products. However, it is used in such small amounts that most of the time it will not make a difference to our customer's products. Uses of E341. Values. Can I produce tablets without Excipients? It contributes to animal’s metabolism, and accelerates growth and development. Overview of pharmaceutical excipients used in tablets and capsules. Dicalcium Phosphate is a Phosphate salt widely used as nutritional supplement in food production. Always store Di-calcium Phosphate in a sealed container with moderate temperatures. Avoid exposure to moisture and extreme temperatures. Magnesium stearate is hydrophobic this means that it will slow the breakdown of a tablet. We comply with the HONcode standard for trustworthy health information -. Dicalcium phosphate [CAS: 7757-93-9], (also known as calcium hydrogen phosphate, phosphoric acid), CAHPO 4, is used in the food industry in the fortification of various products. Usual Adult Dose for Osteoporosis: 1 to 2 tablets orally once a day. It will be white or off-white, odourless and free-flowing. Lactose - Binder, sweetener and bulking agent. Wet Clean - Next you need to perform a wet clean. Medically reviewed by Drugs.com. Can I get a better price than is listed on the website? It used as an anti-caking agent as it can absorb small amounts of moisture. What is the difference between the range of excipients? This should be with the appropriate grade oil or grease considering your use and greasing chart. How to use Calcium Phosphate With Vit D Capsule. Dicalcium Phosphate E341(ii) uses as follows: In Food Production. Most of … Various calcium phosphates are used as diluents in the pharmaceutical industry. Are there any known allergens or health risks? ), allergies, pre-existing diseases, and current health conditions (e.g. Calcium phosphate is a widely used pharmaceutical excipient as binder and filler in solid oral dosage forms which include compressed tablets and hard gelatin capsules. The "di" prefix in the common name arises because the formation of the HPO4 anion involves the removal of two protons from phosphoric acid, H3PO4. Take this medication by mouth with food. This ensures each tablet will be the same. It is also used in the pharmaceutical industry as a pelleting and thickening agent. What is the shelf life? Magnesium Stearate is a dry lubricant and helps again with the movement of ingredients through the machine but also helps with the ejection of the tablets from the machine. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Excipient (pharmacologically inactive substance). Any known factors that can affect the rate, speed up or slow down the breakdown of a tablet? Accessed 03/24/2012, [2] FDA’s SCOGS database; calcium phosphate dibasic; SCOGS-Report Number: 32; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=58. – a coarse grade DI-CAFOS D 160 is the most widely used product for direct compression because of its very good both compaction and flow properties while a fine grade DI-CAFOS D 14 is very popular product used mainly in wet granulation processes. CoA stands for Certificate of Analysis this is also known some times as an MSDS (Material Safety Data Sheet) all of the information contained in a CoA is inside the MSDS for every LFA product which is emailed to you after purchase. It's used in the production of tablets and capsules as a "flowing agent". Dicalcium phosphate is a calcium supplement commonly found in prepared breakfast cereals, in pharmaceuticals as an inert ingredient to bind tablets, and in toothpastes. Diluents are added to pharmaceutical tablets or capsules to make the product large enough for swallowing and handling, and more stable. Disintegrants Disintegrants or disintegrating agents are raw materials that appear in some tablets. What is the mesh size of your excipients? If your product or API is clumpy then you will need to add an anticaking agent. The utilituy of Dicalcium phosphate dihydrate (DCPD), a commonly used water insoluble pharmaceutical excipient, has been investigated for its use in … Diluents are added to pharmaceutical tablets or capsules to make the product large enough for swallowing and handling, and more stable. A granular anhydrous dicalcium phosphate having a particle of a size sufficient for direct compression tablets and a surface area of greater than 5 meters 2 /gram can be direct compression tableted. Choose your local phone number or click "Email Us" to send us a message and for other ways to reach us. Some calcium phosphate salts can be anhydrous, meaning the water has been removed from the salt form. Dicalcium phosphate is used as a food additive, it is found in some toothpastes as a polishing agent and is a biomaterial. Calstar® can be used as an excipient in the preparation of tablets by direct compression or wet granulation. Last updated on Oct 12, 2020. Microcrystalline Cellulose - Binder, filling agent. Silica Dioxide - Flowing agent. Hygroscopic means that they take on water quickly, while hydrophobic means that they repel water. If the amount of MCC you would have to use would be too much or if you do not want to use MCC then you have 3 other options: Ask your supplier for a directly compressible or tabletable grade of your product. Other calcium phosphates are termed dibasic, meaning they have two replaceable hydrogen atoms. It is used as a dough modifier, leavening agent, buffer, emulsifier, and stabilizer in cakes, biscuits, drinks, milk powder, ice cream, flour, baked goods, and pastry. Dibasic calcium phosphate has a high dilution potential and is widely used for those tablet formulations with less than 50% active ingredients. Store - Finally store any of the parts in a cool dry place. There are a number of sanitising solutions available designed to be applied and left on. Some calcium phosphate salts can be anhydrous, meaning the water has been removed from the salt form. It will need to be along side other excipients.Â. For the best experience on our site, be sure to turn on Javascript in your browser. Take this medication by mouth with food. We offer bulk in 500kg, 1 ton, 2 ton and 5 ton lots. [2], [1] Dave RH. Calcium phosphate, tribasic dosing information. At the moment LFA does not sell any supper disintegrants. Chemical Formula. Dicalcium phosphate is mainly used as a dietary supplement in prepared breakfast cereals, dog treats, enriched flour, and noodle products. iii. Additionally, it means that your final products will have consistent ingredients throughout. Di-calcium Phosphate will pass through the digestive system easily. It has many different uses, and is a dietary supplement on its own. This can be found in this section for every excipient. i.e. It can also help with powder flow issues and caking issues. It also helps with cacking issues where powders get stuck to the machine. Di-calcium Phosphate comes in different mesh sizes. The coarser grades supplied here flow well and have excellent compressibility.Â. Wet granulate your product. Dicalcium Phosphate dinyatakan bertujuan untuk merawat tahap kalsium darah rendah, osteoporosis, osteomalacia / riket serta keadaan lain. Yes, there are all of them can be found in the intolerance sheets for each product. Spray dry your product. However, there are not many situations in which this would be a good idea. more granular? This assist powders in flowing smoothly through the machines. Before using Dicalcium Phosphate, inform your doctor about your current list of medications, over the counter products (e.g. Compressibility is the ease at which a powder forms in to a solid tablet. Which excipient should I add if the product doesn't bind well? Usual Adult Dose for Pseudohypoparathyroidism: 1 to 2 tablets orally once a day. Yes, all of our Excipients are extracted from natural sources. This substance is used in the following applications: Dibasic calcium phosphate dihydrate (USP/NF), Calcium Hydrogen Phosphate Dihydrate (Ph.Eur.) We have put together a simple, easy to follow guide to making tablets for yourself or your business. Your body contains 1.2 to 2.5 pounds of calcium. It is also known as dibasic calcium phosphate or calcium monohydrogen phosphate. Dicalcium phosphate is a calcium supplement generally found in pharmaceuticals as an inert ingredient to bind tablets, in prepared breakfast cereals, and in toothpaste. There are two things at play here. This step is recommended by the FDA. Handling Di-calcium Phosphate properly is important for safety and the quality of the product. This product can irritate the eyes and with inhalation may cause mild chest discomfort. You can also take dicalcium phosphate powder. In addition, it is found in some types of toothpaste as well as a calcium supplement in some pharmaceutical preparations. It is not well absorbed and used by the … Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The utilituy of Dicalcium phosphate dihydrate (DCPD), a commonly used water insoluble pharmaceutical excipient, has been investigated for its use in formulating a controlled release matrix type tablet for highly water soluble drugs. Dicalcium phosphate is the calcium phosphate with the formula CaHPO4 and its dihydrate. There are products know as supper disintegrants. Yes. It is, however, important to check the intolerance data. Yes. For this, we recommend magnesium stearate. There is no evidence in the available information on calcium phopshate that demonstrates or suggests reasonable grounds to suspect a hazard to the public when they are used at levels that are now current or that might reasonably be expected in the future. Yes, Dicalcium Phosphate, if used in high amounts, will cause more damage to tooling than just Firmapress or MCC. Advanstar. Dicalcium phosphate – a cheap and inorganic form of calcium, which helps to bulk out tablets. You can get hygroscopic and hydrophobic excipients. The intolerance sheets can be found here: https://www.lfatabletpresses.com/product-data, How to Make Your Own Tablets - Free eBook. Di-calcium Phosphate is an ingredient in a range of different products. Dicalcium phosphate supplements are available as pills, capsules and in complexes for bone support. Dicalcium phosphate anhydrous. Dicalcium phosphate powder has a chalky taste. Dicalcium Phosphate E341(i) is used as nutritional supplement and buffering agent in food such as in biscuits, milk powder, drinks, ice cream, biscuit, breakfast cereals, infant formula, in noodles and baked food. Various calcium phosphates are used as diluents in the pharmaceutical industry. Yes, we have bulk pricing for all of our excipients and it can be found in this section. Available for Android and iOS devices. etc. It is also known as dibasic calcium phosphate or calcium monohydrogen phosphate. If they would like to be sure then they should conduct what is known as a disintegration test. Vegan. It is one of the main calcium phosphates used in animal feeding. What kind of agent is each excipient?/ What is the main use of each excipient? For the best experience on our site, be sure to turn on Javascript in your browser. It is also used as a tableting agent in some pharmaceutical preparations and it is used as a feed for poultry. These products help the breakdown of tablets. Sanitise - Next you need to sanitise the surface. HCaO4P. pregnancy, upcoming surgery, etc. Are all the excipients safe for human consumption? Lubricants exert little or no effect on its bonding properties. Information on this can be found in the products MSDS and Intolerance Data Sheet. Dissolving rate? It is also a mineral phosphorous sources that is often used in organic diets. © 2020 LFA Machines Oxford LTD. All Rights Reserved. Phosphate is a mineral commonly derived from rocks, however, occasionally from bones and whey (from cheese-making). It is not an ingredient found in any natural food. LFA's Di-calcium Phosphate arrives as a crystalline powder. Magnesium stearate - Dry Lubricant. Dicalcium Phosphate is a white, tasteless, microcrystalline powder that is frequently utilized in foods and beverages as a buffering agent, a dough modifier, an emulsifier, a leavening agent, a nutritional supplement, or a stabilizer. Dicalcium phosphate has many purposes. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Tricalcium phosphate (TCP), also known as bone phosphate of lime (BPL), E341, or tribasic calcium phosphate, is a calcium salt of phosphoric acid. 1). vitamins, herbal supplements, etc. Usual Adult Dose for Osteomalacia: 1 to 2 tablets orally once a day. Dicalcium Phosphate is a flowing agent and helps move ingredients through the machine before they are compressed. Dicalcium Phosphate Dosage. Phosphorous and Calcium to a consumers diet will improve bodily functions in many ways. Firmapress - 2 years form batch date.Dextrose - 3 years from batch date.Dicalcium Phosphate - 3 years from batch date.Microcrystalline Cellulose - Magnesium stearate - Lactose - 2 years from batch date.Silica Dioxide - 2 years from batch date. Use our Firmapress ready mix as more than this can be anhydrous, they... 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